Comparative Study of the Antibacterial Activity, Total Phenolic and Total Flavonoid Content of Nine Hypericum Species Grown in Greece

Hypericum perforatum is an herb whose use dates back centuries. Extracts of the plant are available as over-the-counter treatment options for depression. The genus consists approximately 500 species, most which have not yet been studied. Antimicrobial resistance has reached alarming levels, indicating a post-antibiotic era many become less effective. For this reason, nine species were studied their antimicrobial activity and total phenolic flavonoid content. tested against Gram-negative Gram-positive bacteria. inhibited growth bacteria (Staphylococcus aureus Enterococcus faecalis). lowest MIC MBC values calculated extract H. both microorganisms tested, reaching 0.06 mg/mL S. 0.13 E. faecalis. Total content was highest in (86 ± 12.90 mg GAE/g dry material). tetrapterum presented content, equal to 1.58 0.4 RE/g material. herein common or examined compared perforatum; therefore, our study adds new data knowledge Hypericum.